![]() ![]() ![]() LANGUAGE OF ORIGINAL DOCUMENT: English DOCUMENT TYPE: Article SOURCE: ScopusĪdaui, V., Castillo, D., Zimic, M., Gutierrez, A., Decuypere, S., Vanaerschot, M., de Doncker, S., Schnorbusch, K., Maes, I., van der Auwera, G., Maes, L., Llanos-Cuentas, A., Arevalo, J., Dujardin, J.-C. Interestingly, the polyphyletic pattern observed here is very similar to the one we observed in the anthroponotic Leishmania donovani (Laurent et al., 2007), hereby questioning the role of transmission and/or chemotherapeutic drug pressure in the observed population structure. braziliensis might be explained by (i) independent events of drug resistance emergence, (ii) sexual recombination and/or (iii) other phenomena mimicking recombination signals. The finding of a polyphyletic pattern among the Sb V-resistant L. No correlation was found between the genotypes and in vitro drug susceptibility or clinical treatment outcome. The genetic variability in the Peruvian isolates was high and the multilocus genotypes were strongly differentiated from each other. AFFILIATIONS: Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru Department of Parasitology, Unit of Molecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium Laboratory of Animal Diversity and Systematics, Katholieke Universiteit Leuven, Leuven, Belgium Department of Medical Genetics, University of Antwerp, Antwerp, Belgium Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru ABSTRACT: In order to understand the epidemiological dynamics of antimonial (Sb V) resistance in zoonotic tegumentary leishmaniasis and its link with treatment outcome, we analyzed the population structure of 24 Peruvian Leishmania braziliensis clinical isolates with known in vitro antimony susceptibility and clinical phenotype by multilocus microsatellite typing (14 microsatellite loci). TI: Multilocus genotyping reveals a polyphyletic pattern among naturally antimonyresistant Leishmania braziliensis isolates from Peru SO: (2011) Infection, Genetics and Evolution, 11 (8), pp. PUBLICACIONES UPCH EN REVISTAS INTERNACIONALES 2011Īdaui, V., Maes, I., Huyse, T., Van den Broeck, F., Talledo, M., Kuhls, K., De Doncker, S., Maes, L., Llanos-Cuentas, A., Schönian, G., Arevalo, J., Dujardin, J.-C. UNIVERSIDAD PERUANA CAYETANO HEREDIA Dirección Universitaria de Gestión de la Información Científica ![]()
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